CORDIS Project
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This project focuses on developing advanced viral vectors for gene therapy, specifically targeting genetic disorders. It aims to enhance gene delivery efficiency to human muscle cells and enable the transfer of larger genes by engineering bacteriophage-based vectors and incorporating nanobodies for improved specificity…
Gene therapies are a fast becoming a realistic treatment for patients suffering from genetic disorders.
To date, systemically applied invivo gene therapies exclusively rely on adeno-associated viral (AAV) vectors for gene delivery to affected cells. AAV vectors have manyfeatures that make them successful gene delivery tools and through biomining and bioengineering efforts over the years, AAVvariants are able to transduce a number of clinically relevant targets.
However, many cell types, includin…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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