CORDIS Project
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This project aims to uncover the mechanisms behind non DNA-sequence based inheritance, specifically transgenerational epigenetic inheritance, using the model organism Caenorhabditis elegans. It will identify key epigenetic marks that facilitate information transfer across generations.
Non DNA-sequence based inheritance has been observed in many organisms from microbes to man and likely impacts public health.
The mechanisms of non DNA-sequence based inheritance remain largely unknown.
However, some examples of non DNA-sequence based inheritance in mammals, plants and invertebrates are linked to the control of selfish, transposable elements in the genome.
Here we propose to discover the mechanistic basis of multi-generational non DNA-sequence based inheritance, also referred to…
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