CORDIS Project
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This project investigates the mechanisms behind telomere dysfunction and its role in genomic instability and cancer development. It aims to identify genetic factors involved in the telomere damage response and their implications for aging and cancer therapies.
Telomeres are specialized nucleoprotein complexes that protect chromosome ends against recognition as DNA breaks.
In somatic cells telomeres shorten every cell division, eventually compromising telomere function.
This leads to activation of a DNA damage response that induces irreversible growth arrest or cell death and serves to suppress tumorigenesis by preventing outgrowth of incipient cancer cells.
Furthermore, by limiting replicative potential, telomere dysfunction contributes to aging.
Howe…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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