CORDIS Project
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This project explores how Sonic Hedgehog signaling influences cell fate in the developing central nervous system. It investigates the timing and concentration of this signaling to understand its role in neural differentiation.
The central nervous system (CNS) is the most complex organ in the vertebrate body, and the patterning of the developing CNS is comprised of a large number of regulatory steps.
Many extracellular molecules play critical roles in the precise patterning of the CNS during embryonic development.
Among them, Sonic Hedgehog (Shh), a soluble factor produced by the floor plate and notochord, is a strong candidate for the determination of the cell fates in the ventral neural tube.
Shh has the characterist…
MEDICAL RESEARCH COUNCIL
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