CORDIS Project
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This research explores the roles of TORC1 and TORC2 protein complexes in cellular growth and tension regulation. By developing new chemical tools, the project aims to uncover mechanisms of growth control and potential therapeutic targets.
The target of the bacterial macrolide rapamycin, TOR, is a ser/thr protein kinase that assembles into two distinct protein complexes, conserved from yeast to human, we named TORC1 and TORC2. TORC1 is directly bound and inhibited by rapamycin and studies with rapamycin have revealed that TORC1 plays a central role in coupling nutrient cues to biomass synthesis and turnover.
The lack of a specific inhibitor for TORC2 has made the study of this complex much more challenging.
We overcame this challe…
UNIVERSITE DE GENEVE
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