CORDIS Project
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This project investigates how stress affects ribosomal frameshifts and their role in RNA turnover, which is crucial for gene expression adaptation. Using advanced techniques, it aims to explore the relationship between RNA degradation and telomere maintenance in response to environmental changes.
Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment.
It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool.
Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress.
One of the most studied mechanisms controlling RNA turnover is nonsense-mediated deca…
KAROLINSKA INSTITUTET
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