CORDIS Project
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This project investigates the role of telomeres and their associated RNA, TElomeric Repeat containing RNA (TERRA), in maintaining genome stability and regulating cell division. It aims to understand how telomeres protect against DNA damage and how their functions can be manipulated in cancer cells.
The ends of eukaryotic chromosomes, known as telomeres, play crucial roles as guardians of genome stability and tumor suppressors.
Telomeric DNA is maintained by the ribonucleoprotein enzyme telomerase.
Most normal human somatic cells express only very low levels of telomerase and telomeres shorten with continuous cell division cycles.
Ultimately, short telomeres activate a DNA damage response that leads to a permanent cell cycle arrest or apoptosis.
Reactivation of telomerase is a key requisite…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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