CORDIS Project
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This project aims to understand how T lymphocytes achieve self-tolerance, distinguishing between harmful and harmless antigens. It focuses on the mechanisms of T cell selection in the thymus, exploring how these processes can lead to autoimmune conditions.
One of the central mysteries of immunology is self-tolerance.
How does the human body select ~10e12 T lymphocytes, that are reactive to foreign pathogens but tolerant to normal cellular constituents of the host?
Over the last few years, my laboratory identified 2 fundamental mechanisms used by thymocytes to establish T cell tolerance.
We demonstrated that the affinity threshold for negative selection is a constant for all thymocytes expressing MHC I restricted TCRs.
This binding affinity thresho…
UNIVERSITATSSPITAL BASEL
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