CORDIS Project
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This project investigates the role of tumor endothelial cells in cancer immunotherapy resistance. By studying mice lacking a specific protein, the research aims to understand how these cells contribute to immunosuppression and the effectiveness of anti-cancer treatments.
Immunotherapy, in the form of immune checkpoint inhibitors, is the upcoming anti-cancer therapy, but suffers resistance in large fractions of cancer patients (also lung cancer).
Tumors stimulate angiogenesis to ensure their supply of nutrients, however much less studied is how tumor endothelial cells (TECs) contribute to immunosuppression.
Endothelial cells (ECs) represent a major non-hematopoietic component of immunity and TECs are presumed to be immunosuppressive, in part by expressing elevate…
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