CORDIS Project
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This project explores the relationship between testosterone levels and spermatogenesis in the context of male hormonal contraception. It aims to identify optimal testosterone treatment regimens that effectively suppress sperm production while maintaining necessary androgen actions.
Follicle-stimulating hormone and high intratesticular (IT) testosterone (T) level are required for qualitatively normal spermatogenesis.
Treatment with T has been successfully tested in male contraception, because it can abolish gonadotrophin secretion through enhanced negative feedback action and arrest spermatogenesis.
However, none of the T treatment regimens tested have resulted in complete azoospermia in all men, for reasons not yet understood.
After complete T induced suppression of gonado…
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