CORDIS Project
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This project explores how the nematode Caenorhabditis plicata defends its germline against transposable elements without the typical piRNA pathway. It aims to identify novel small RNA mechanisms and their evolutionary origins, contributing to our understanding of genome protection and evolution.
The germline is the only immortal lineage in animals, making it a target for transposable elements (TEs) to perpetuate themselves at the host's expense.
To counter these threats, animals utilize Piwi-interacting RNAs (piRNAs) to suppress TEs and maintain germline integrity.
Despite the crucial role of piRNAs, the diversity of mechanisms organisms use to repress parasitic elements remains largely unexplored.
To address this, I propose studying an emerging model system, the nematode Caenorhabditis…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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