CORDIS Project
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This project develops a new toolkit to study how transcription factors bind to DNA within the chromatin of lung cancer cells. By analyzing binding kinetics and the influence of chromatin and DNA on these processes, it aims to create predictive models for transcription factor behavior in various cellular states.
Transcription factor binding is orchestrated by a complex interplay between DNA sequence, chromatin composition, protein interactions, and transcription factor concentration.
These regulatory features determine the binding kinetics: how long it takes for a certain amount of transcription factor to associate, and subsequently dissociate from specific binding sites.
These kinetics are in turn determined by the thermodynamic properties of each interaction.It is currently not possible to measure the…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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