CORDIS Project
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This project investigates the mechanisms regulating lipid synthesis in cells, particularly in relation to nonalcoholic fatty liver disease. By studying the enzyme DGAT2, it aims to uncover new insights into lipid homeostasis and potential therapeutic targets for metabolic disorders.
The ability of cells to precisely maintain an internal steady state of lipids is essential for life.
While homeostatic mechanisms controlling specific lipids such as sterols are well characterized, the regulation and coordination of fatty acid (FA) and triacylglycerol (TG) synthesis remains largely unknown.
Several common metabolic disorders, including obesity and type 2 diabetes, lead to nonalcoholic fatty liver disease (NAFLD), a condition characterized by increased accumulation of hepatic TGs…
KAROLINSKA INSTITUTET
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United States, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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