CORDIS Project
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This project investigates the molecular mechanisms that regulate the connectivity of a specific neuronal circuit involved in sensory processing, particularly in relation to disorders like autism and schizophrenia. By analyzing cell surface proteins and their impact on synaptic function in mice, the research aims to unc…
Sensory processing is frequently altered in disorders like autism, schizophrenia and bipolar disorder.
Neuronal circuits from the thalamus to the primary somatosensory cortex (S1) play a critical role in sensory processing.
Dysconnectivity of such circuits is implicated in disorders associated with sensory processing impairments.
The posteromedial thalamic nucleus (POm) connects to intratelencephalic (IT) layer 5 (L5) pyramidal neurons (PNs) of S1, regulating somatosensory processing.
The mechan…
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