CORDIS Project
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This project studies the ubiquitin conjugation system, which regulates protein fate in cells. It aims to reconstitute the entire ubiquitination process on specific targets to understand the mechanisms involved in genome maintenance.
Ubiquitin conjugation is one of the most important signaling systems in the eukaryotic cell.
Different types of mono- and polyubiquitin chains determine the fate of target proteins by redirecting them for degradation, relocalization or interaction with new partners.
The type of ubiquitin modification on any target is determined by the interplay between the conjugating E2/E3 complexes on the one hand and deubiquitinating enzymes on the other.
In practice, it is the balance between conjugating and…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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