CORDIS Project
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The Secret Surface project investigates the role of tetraspanins in tumor cells, focusing on how their disrupted interactions contribute to cancer development. By analyzing lymphoma cells, the project aims to uncover the molecular mechanisms behind tetraspanin function and its implications for cancer therapies.
Cancer development is characterized by uncontrolled proliferation, cell survival and metabolic reprogramming.
Tumour cells are surrounded by a fluid-mosaic membrane that contains tetraspanins (Tspans) which are evolutionary conserved proteins important in the formation of multiprotein complexes at the cell surface (‘tetraspanin web’).
Increasing evidence indicates that Tspans are involved in cancer, still the architecture of the Tspan web in native tumour membranes and its (patho)physiological f…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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STICHTING RADBOUD UNIVERSITEIT
Netherlands, Nijmegen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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