CORDIS Project
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This project investigates the role of DNGR-1, a receptor on dendritic cells, in recognizing dead cells and presenting their antigens to T-cells. It aims to understand how DNGR-1 influences the internal trafficking of these cells and its impact on immune responses.
Dendritic cells (DCs) play an essential function in initiating adaptive immunity.
Key to DC function are receptors for recognizing and capturing pathogens and damaged cells and for controlling subsequent antigen extraction, processing and presentation. DNGR-1 (also known as CLEC9A) is a DC-restricted C-type lectin receptor (CLR) that recognizes the actin cytoskeleton exposed on necrotic cells. DNGR-1 is not required for internalization of cell corpses by DCs but regulates their subsequent abilit…
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