CORDIS Project
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This project explores the role of the Spichthyin protein in regulating Bone Morphogenetic Protein signaling in neurons. It aims to identify binding partners and understand the intracellular trafficking pathways of these proteins, which are crucial for neuronal function and development.
Spichthyin (Spict) is the Drosophila homolog of the human disease genes SPG6 (mutated in some hereditary spastic paraplegias) and ichthyin (mutated in some ichthyoses).
The host lab has recently assigned a cellular role to this protein family, by showing that Spict is an endosomal membrane protein that antagonises the BMP signaling pathway in neurons and S2 cells, causing internalisation of receptors from the cell surface to the endosome.
The main goal of this project is to understand how Spict…
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