CORDIS Project
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This project investigates how retinoic acid, a vitamin A metabolite, influences the immune system by altering the behavior of γδ T cells. It aims to understand its role in autoimmune diseases like psoriasis and multiple sclerosis, potentially leading to new immunotherapy strategies.
Retinoic acid, the active metabolite of vitamin A, is implicated in a broad range of well-studied pre- and post-natal functions.
By comparison, its involvement in the development and function of the immune system remains largely unknown.
However, it has recently been shown that retinoic acid has a protective effect in a murine model of colitis by switching the cytokine production by γδ T cells from pro- (IL-17A) to anti-inflammatory (IL-22).
At the border between innate and adaptive immunity, γδ…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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