CORDIS Project
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This project focuses on understanding the immune response to neoantigens in cancer using a humanized mouse model. It aims to identify why certain T cells fail to reject tumors and to develop strategies for enhancing immunotherapy effectiveness against cancers.
Cancer is a global health burden and the second leading cause of death worldwide.
In recent years, the development of immunotherapy has revolutionised the approach to cancer therapy. A significant limitation, however, is that it is only effective in a subset of patients and the biggest challenges remain the identification of immunogenic targets on human cancers and overcoming immunosuppression.
Neoantigens, which are newly formed antigens that arise from mutated tumour proteins, are promising ta…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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