CORDIS Project
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This project investigates the role of a specific liver receptor, SR-BI, in the infection process of malaria-causing Plasmodium parasites. By examining how cholesterol uptake through SR-BI affects the invasion of liver cells, the research aims to identify potential strategies for malaria prevention.
Plasmodium parasites are the causative agents of malaria, amongst the most prevalent and severe human infectious diseases.
Liver infection by Plasmodium sporozoites is the first obligatory step of malaria and a quite attractive target for prophylactic strategies against the disease.
At this stage, each sporozoite invades a single hepatocyte and develops into thousands of merozoites that are released into the bloodstream.
Preliminary results of the host laboratory clearly show that a hepatocyte r…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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