CORDIS Project
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This project explores how fluctuations in gene expression allow bacteria to adapt to environmental changes, particularly focusing on antibiotic resistance. It employs single-cell microscopy and synthetic biology to understand the mechanisms behind these adaptive strategies.
Gene circuits exhibit fluctuations (‘noise’) in the levels of key components such as regulatory proteins.
Increasingly, noise appears to play functional roles, e.g it can enable a subpopulation of cells to enter a transient antibiotic-resistant state, enhancing their survival.
By ensuring that cells do not all exist in the same transcriptional state, the colony can ‘bet-hedge’ against future environmental changes.Studying bet-hedging is critical to our understanding of how bacterial gene circui…
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