CORDIS Project
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This project investigates the highly calcium-sensitive pool of insulin secretory granules in pancreatic beta-cells, focusing on their role during insulin secretion. By combining experimental techniques and modeling, it aims to enhance understanding of insulin release mechanisms relevant to diabetes.
Insulin is released from the pancreatic beta-cells in a biphasic manner in response to a step in the ambient glucose concentration, and the loss of first-phase secretion is an early marker of diabetes.
Studies have shown that there exist pools of insulin secretory granules with different calcium sensitivities.
The project will study the nature, regulation and role of the highly calcium-sensitive pool (HCSP) in pancreatic beta-cells.
Special focus will be on its relation to newcomer granules", wh…
MAX IV Laboratory, Lund University
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