CORDIS Project
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This project investigates the role of bone marrow-derived endothelial precursor cells in tumor angiogenesis and growth, particularly after cytotoxic treatments. It aims to identify host factors that influence these cells and explore new treatment strategies to inhibit tumor regrowth and metastasis.
One of the more important recent developments in clinical oncology has been the approval of antiangiogenic drugs for the treatment of various types of cancer.
We have found that these drugs not only act locally to inhibit the formation of new blood vessel capillaries in tumors, but also systemically by targeting bone marrow-derived endothelial precursor cells (CEPs).
It has been suggested that other bone marrow-derived cell (BMDC) types contribute to tumor angiogenesis and growth by either direc…
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