CORDIS Project
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This project investigates the genetic variability of the Hepatitis C virus in HIV co-infected patients to understand its impact on treatment resistance. It aims to clone specific viral sequences to enhance the development of effective therapies.
Hepatitis C virus (HCV) is a major cause of premature death due to cirrhosis and hepatocellular carcinoma in a large proportion of the world population (>25 million).
Recently, advances in the development of new therapeutic compounds to treat HCV have revealed several potent inhibitors of the HCV serine protease, which have reached clinical trials.
However HCV has a high genetic variability, not only between genotypes but also between quasispecies of an infected individual.
In HIV coinfected pat…
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL CARLOS III
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