CORDIS Project
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The project explores the influence of retrotransposons on human gene expression, particularly in neural development. By studying the role of these mobile DNA elements, it aims to uncover their impact on neurological disorders and the evolution of human-specific gene regulatory networks.
Throughout evolution, primate genomes have been under attack by different classes of retrotransposons, retrovirus-derived mobile DNA elements.
As a result, an astonishing ~50% of the human genome is derived from many types of retrotransposons. I previously showed that primate-specific retrotransposon invasions are restricted by primate-specific KRAB zinc finger proteins.
These findings suggest that through recruitment to thousands of new genomic locations, KRAB zinc finger proteins have become i…
UNIVERSITEIT VAN AMSTERDAM
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