CORDIS Project
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This project investigates how cells maintain developmental flexibility by studying the molecular mechanisms that regulate gene expression. It focuses on the role of cohesin, a protein complex, in gene regulation and aims to visualize gene activity in real time within the cell's three-dimensional structure.
How cells retain, lose, and regain developmental plasticity is poorly understood due to ignorance of the molecular mechanisms regulating gene expression.
Each gene is regulated by a unique set of factors and as a consequence the trans-acting factors and cis-acting chromatin modification states regulating a given gene are extremely rare.
Transcription is affected by events taking place many thousands of base pairs away from the start, a property enabling developmental and evolutionary plasticity,…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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