CORDIS Project
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This project aims to elucidate the structure and function of nuclear pore complexes, which regulate macromolecule transport in cells. It will develop biomimetic systems to study transport selectivity and potentially create new biotechnology applications.
Nuclear pore complexes (NPCs) are the exclusive gate of entry/exit of macromolecules into and out of the nucleus of living cells.
They exhibit a unique selectivity in transport, with respect to size and molecular species: very small molecules can diffuse efficiently through the pore, while larger objects are delayed/blocked unless they are bound to specialized proteins, so called nuclear transport receptors (NTRs).
The permeability barrier and its selectivity arise from an assembly of protein do…
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
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