CORDIS Project
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This project investigates the genetic mechanisms behind the evolution of digits in tetrapods by comparing gene expression in zebrafish and mice. It aims to clarify how regulatory elements influenced limb development.
The fossil record suggests that fish fins suffered sequential transformations, giving rise to limbs close to the origin of tetrapods.
However, the molecular mechanisms that underlie this evolutionary transition remain unclear.
Interestingly, Hoxd genes exhibit a single phase of expression during zebrafish fin development but, in contrast, are expressed in two independent phases during mice limb development.
The second phase is essential for digit development, the main innovation of the tetrapod…
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