CORDIS Project
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This project investigates the role of a specific protein complex in cellular processes like autophagy and cell division. By analyzing its functions and mechanisms, it aims to understand its potential as a target for cancer therapy.
Phosphoinositides (PIs), phosphorylated derivatives of phosphatidylinositol (PtdIns), control cellular functions through recruitment of cytosolic proteins to specific membranes.
Among the kinases involved in PI generation, the PI3K-III complex, which catalyzes conversion of PtdIns into PtdIns 3-phosphate (PI3P), is of great interest for several reasons.
Firstly, it is required for three topologically related membrane involution processes - the biogenesis of multivesicular endosomes, autophagy, a…
UNIVERSITETET I OSLO
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