CORDIS Project
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This project investigates the role of coagulation factor XII and polyphosphate in cancer-related blood clotting and tumor growth. It aims to develop safe anticoagulation therapies that minimize bleeding risks while also targeting cancer proliferation.
Cancer is a leading cause of venous thrombosis.
Tumor-driven procoagulant mechanisms and therapies for interference with cancer-associated thrombosis are poorly developed and are associated with life-threatening bleeding complications.
Coagulation factor XII is a protease that is essential for thrombus formation while being dispensable for hemostatic processes that terminate blood loss.
Challenging the dogma of a coagulation balance, targeting factor XII protects from thromboembolic disease with…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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