CORDIS Project
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This project investigates how the three-dimensional structure of sister chromatids influences the efficiency and choice of DNA double-strand break repair in human cells. It employs advanced chromosome conformation capture technology to explore the molecular factors that regulate chromosomal organization and their role…
The integrity of eukaryotic genomes is constantly challenged by various endogenous and exogenous insults, whereby DNA double-strand breaks (DSBs) are particularly problematic.
DSBs can be repaired by multiple pathways, but only the homologous recombination (HR) pathway ensures error-free repair.
HR restores missing information around the lesion based on topological interactions with a homologous region on a distinct DNA molecule.
HR-directed repair can function across homologous chromosomes in d…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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