CORDIS Project
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This project investigates the role of specific proteins in mitochondrial function and their connection to neurodegenerative diseases. By using cellular and animal models, it aims to understand how these proteins contribute to energy production and the misassembly of mitochondrial complexes in conditions like Alzheimer'…
Mitochondria have a crucial role in cell survival and apoptosis, in particular in long-lived cells such as neurons.
Mitochondria generate energetic potential through respiratory complexes I to IV, which constitute the electron transport chain. A number of studies demonstrates that mitochondrial integrity declines as a function of aging and dysfunctions may be exacerbated by age-related neurodegenerative diseases.
Altered levels of complex I proteins have been found to be directly responsible for…
UNIVERSITA DEGLI STUDI DI TRENTO
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