CORDIS Project
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This project investigates the role of the protein DREAM in Alzheimer's disease, focusing on its impact on calcium signaling and synaptic dysfunction. By studying various DREAM mutants and their effects, the project aims to identify potential therapeutic targets for treating Alzheimer's.
Alzheimer's disease (AD) is the most common form of age-related dementia.
This neurodegenerative disorder is characterized by massive neuronal death and deposition of amyloid-β peptide (Aβ), which is formed by processing of amyloid precursor protein (APP).
The mechanism of neuronal degeneration in AD are not well understood, but growing evidence shown that neuronal death is at least in part due to dysregulated Ca2+ signalling.Calsenilin/DREAM was identified as a Ca2+-binding protein that interac…
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