CORDIS Project
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This project explores the role of specific proteases, known as granzymes, in the immune response to bacterial sepsis. By studying both mouse models and human patients, it aims to clarify how these enzymes contribute to inflammation and host defense during severe infections.
Sepsis, the systemic inflammatory host response to infection, is a major health problem.
Inflammation is considered the first line of defence in host-pathogen interactions.
Granzymes (grzs) are a family of proteases released from secretory granules that have been suggested to have relevant effects in inflammation.
Outstanding findings are the rationale to hypothesize that granzymes play an essential role in the host response to bacterial sepsis: various bacteria can induce release of GrzA and B…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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