CORDIS Project
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This project aims to elucidate how human hematopoietic stem cells respond to low oxygen environments. By studying the role of hypoxia-inducible factors, the research seeks to link oxygen levels to stem cell maintenance and leukemia development.
Mammalian haematopoiesis in the adult takes place predominantly in the bone marrow (BM) where a population of haematopoietic stem cells (HSC) are located. HSC are able to self-renew and give rise to all the blood cell types.
The fate choice of HSC to either self-renew or differentiate is controlled by an interplay between intrinsic mechanisms and extrinsic signals from the surrounding environment called stem cell niche.
The existence of a hypoxic niche in the BM has been highlighted in the last…
CANCER RESEARCH UK LBG
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