CORDIS Project
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This project investigates the imprinted gene Kcnk9, which encodes a potassium channel protein, to understand its role in the central nervous system. By using gene targeting in mice, the research aims to explore the effects of Kcnk9 deficiency on development and neurodevelopmental processes.
Genomic imprinting is the epigenetic marking of a subset of genes which results in monoallelic or predominant expression of one of the two parental alleles according to their parental origin.
In my previous work, I discovered the imprinted expression of the Kcnk9 gene in mice and humans.
Kcnk9 is a member of the two-pore (2P)-domain K+ channel family and encodes for the potassium channel protein TASK-3.
This family of K+ channels was already shown to play a critical role in both cell apoptosis a…
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