CORDIS Project
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This project investigates the role of the p110a isoform of phosphoinositide 3-kinase in cancer. It aims to understand its mechanisms in oncogenesis and identify potential molecular pathways for cancer intervention, particularly focusing on cell senescence and the effects of specific mutations.
Mammals have 8 distinct isoforms of PI3K.
One of the key PI3K isoforms in cancer is p110a, as this isoform is extremely frequently activated by mutation.
How p110a achieves this function is not clear, and my main aim is to investigate the role and mechanism of action of p110a in an oncogenic context, to provide a comprehensive picture of the molecular events controlled by p110a, and to identify molecular pathways interacting with p110a signalling.
This is anticipated not only to provide a bette…
QUEEN MARY UNIVERSITY OF LONDON
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