CORDIS Project
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This research explores the role of the p16INK4a protein in the development of insulin resistance and obesity by studying macrophage behavior. The project includes experiments to analyze metabolic parameters and the molecular mechanisms influencing macrophage polarization.
Genome-wide association studies have linked the CDKN2A locus to an increased risk of Type 2 Diabetes (T2D), which is mostly accompanied by insulin resistance (IR) and obesity.
The CDKN2A locus encodes p16INK4a, a tumor suppressor. p16INK4a is an inhibitor of cyclin-dependent kinases, which regulate the cell cycle.
Recent studies have shown a link between p16INK4a and the control of inflammation. T2D is an inflammatory disease, in which macrophages are important effector cells.
Moreover, adipose…
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