CORDIS Project
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This project investigates the role of Rho GEF proteins in regulating Rho-family GTPases, focusing on their impact on epithelial cell morphogenesis using a three-dimensional kidney cell model. The research aims to identify key Rho GEFs involved in cell behavior, which may have implications for understanding cancer and o…
Rho-family GTPases control many aspects of cell behavior through the regulation of multiple signaling pathways.
Failure to properly regulate Rho GTPases can have deleterious consequences in human development and disease. A key group of spatial and temporal regulators of Rho-family GTPases are the Rho GEF proteins.
Rho GEFs serve to couple diverse regulatory stimuli to Rho GTPase activation.
There are a large number of Rho GEFs encoded by the human genome and a systematic study addressing cellula…
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