CORDIS Project
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This project investigates the role of the p110δ isoform of phosphoinositide 3-kinases in regulating dendritic cell functions, particularly in immune responses and allergic diseases. By examining the interaction between p110δ and phosphatase PTEN, the research aims to uncover mechanisms that control immune cell behavior…
Phosphoinositide 3-kinases (PI3K) regulate many signalling events, having wide implications for cell biology in many cell types.
Among the various catalytic subunit isoforms, p110 is expressed only in some leukocyte cells and was shown to have important potential for the regulation of immune responses.
This PI3K isoform was shown to control development of allergic lung disease by affecting Th2 differentiation.
Recently, p110 has been proposed to selectively control the production of the pro-al…
UNIVERSITEIT GENT
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