CORDIS Project
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This project investigates how proteins in T cells interact within complex signaling networks, focusing on their spatial and temporal organization. By using advanced imaging techniques, it aims to understand T cell activation in health and disease, particularly in autoimmune disorders and cancer.
Understanding how cellular activation occurs in complex signaling networks is an important challenge in particular in multi-genic diseases such as autoimmune disease, type II diabetes, and cancer. A critical component of signaling complexity is that proteins inside live cells enrich at particular locations and times.
Co-enrichment of two proteins enhances their interaction efficiency.
At the systems scale, such patterning thus determines how regulatory information flows through signaling network…
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