CORDIS Project
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This research focuses on understanding the early stages of cancer development, specifically the role of chromosome instability in tumor formation. By analyzing genetic changes in human tissues, the project aims to identify critical factors that lead to malignancy and improve early detection strategies.
Cancer starts years to decades before diagnosis.
Yet, early stages of tumor development are poorly understood.
In particular, the precancer landscape of chromosome instability (CIN) is understudied, due to the scarcity of precursor lesions and methods to analyze CIN in single cells.
The research presented here will address how the instability rate of the genome, followed by selection, determines whether a CIN-driven tumor arises. I hypothesize that the onset of CIN is the tipping point that gove…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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