CORDIS Project
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This project investigates the role of THEMIS1 protein in T cell signaling and immune responses. By studying knockout mice, the research aims to understand how THEMIS1 influences T cell development and its potential link to autoimmune diseases.
A critical step of an immunological response is the activation of T lymphocytes through intracellular signaling pathways downstream of T cell receptors (TCR). THEMIS1 is a new actor of T cell signaling that belongs to a newly identified family of proteins. THEMIS proteins each contain a previously uncharacterized globular domain (called 'CABIT') whose structure and function are currently unknown.
We generated THEMIS1 knockout mice and show that this protein is essential for developing T cells in…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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