CORDIS Project
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This project investigates the role of specific genetic mutations in colorectal cancer, particularly in patients with Lynch Syndrome. It aims to evaluate the effectiveness of a new therapeutic approach using inhibitors that target the Wnt/beta-catenin signaling pathway in tumors with these mutations.
Colorectal cancer (CRC) is a leading cause of death worldwide.
Mutations in components of the canonical Wnt/beta-catenin pathway such as APC, CTNNB1/beta-catenin, AXIN2 and more recently RNF43 or ZNRF3 can contribute to CRC tumorigenesis.
The hosting team and Dr.
Clevers’ group have recently described that inhibitors of the porcupine enzyme, that is essential for the maturation of Wnt-ligands, have therapeutic efficacy in tumors with RNF43 and ZNRF3 mutations.
Hypermutant tumors are characterize…
FUNDACION PRIVADA INSTITUTO DEINVESTIGACION ONCOLOGICA DE VALL-HE
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
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