CORDIS Project
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This project focuses on engineering new enzymes by incorporating thiazolium amino acids into a retro-aldolase enzyme. The goal is to create biocatalysts that can perform organocatalytic reactions more efficiently and sustainably than traditional chemical catalysts, with potential applications in medicine and industry.
The design of enzymatic catalysts and protein therapeutics with tailored, new-to-nature properties is a long-standing goal in enzymology and cell biology.
Nature generally uses 20 amino acids as building blocks for protein synthesis.
However, this portfolio limits the options for engineering proteins with ‘un-natural’ activities.
Recent developments in the expansion of the genetic code have the potential to revolutionise the design of novel enzymes; by reprogramming the genetic code, we could co…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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