CORDIS Project
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This project focuses on developing biocatalytic methods for synthesizing chiral thiols and thioethers, which are important components of active pharmaceutical ingredients. By utilizing enzymes, the project aims to create more sustainable and efficient synthesis routes, expanding the chemical tools available for drug de…
Active pharmaceutical ingredients (APIs) are crucial for public health.
However, their synthesis is often challenging due to the high complexity of modern drug molecules.
In particular, APIs need to have well-defined chirality as opposite enantiomers can have dramatically different biological effects.
Yet, the synthesis of chiral centres is often challenging and toxic metals as well as harsh reaction conditions are often required.
Enzymes on the other hand can often achieve unmatched enantiosele…
TECHNISCHE UNIVERSITEIT DELFT
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