CORDIS Project
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This project investigates how changes in T helper cell states are regulated at the genetic and epigenetic levels. Using advanced sequencing techniques, it aims to uncover the mechanisms driving differentiation and plasticity in these immune cells, focusing on gene expression patterns and regulatory interactions.
The central question of this proposal is: how are changes in cell state regulated at the transcriptomic and epigenetic level? I will tackle this question using an integrated computational and experimental approach with the T helper cell system as my model.
The Th system consists of a naïve precursor cell type, and four main differentiated cell types that have some capacity to interconvert, known as plasticity.
The experiments will be designed to measure both entire transcriptomes and single mRNA…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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