CORDIS Project
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This research investigates the development and function of thymic epithelial cells, which are crucial for T cell maturation and self-tolerance. The project aims to uncover the molecular mechanisms that regulate these processes and their implications for autoimmunity.
Central tolerance is shaped in the thymus, a primary lymphoid organ, where immature T lymphocytes are “educated” into mature cells, capable of recognizing foreign antigens, while tolerating the body’s own components.
This process is driven mainly by two separate lineages of thymic epithelial cells (TECs), the cortical (cTEC) and the medullary (mTEC).
While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and…
WEIZMANN INSTITUTE OF SCIENCE
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