CORDIS Project
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This project explores the thyroid gland's ability to resist oxidative stress and its implications for thyroid health and cancer. It focuses on the role of the Nrf2 transcription factor in regulating antioxidant defenses, particularly under conditions of iodine deficiency and in thyroid cancer.
Recently, it has been discovered that the thyroid gland has increased ability to withstand oxidative stress compared to other organs.
This important feature allows the gland to maintain its homeostasis in the face of increased burden of free radicals produced during iodine metabolism for thyroid hormone synthesis.
Iodine deficiency and goiter are associated with increased oxidative stress in the thyroid.
While some antioxidant enzymes are known to be upregulated in the thyroid under such conditi…
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